14-Day Backpacking Route Through South America

Exploring South America on a 14-day backpacking trip is a thrilling experience that combines breathtaking landscapes, vibrant cultures, and unforgettable adventures. From the high peaks of the Andes to lush jungles and colorful colonial towns, this itinerary is designed for adventurous travelers seeking diversity and depth without breaking the bank.

Day 1–3: Bogotá, Colombia

Highlights: Monserrate, La Candelaria, Gold Museum
Start your journey in Colombia’s capital city. Bogotá’s mix of old and new is a perfect introduction to the continent. Hike up Monserrate for panoramic views, stroll through the artistic La Candelaria district, and explore the extensive collection at the Gold Museum. Don’t miss a cup of world-class Colombian coffee.

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Day 4–5: Medellín, Colombia

Highlights: Comuna 13, cable cars, Plaza Botero
Take a short flight or overnight bus to Medellín, a city that’s transformed from its troubled past into a vibrant cultural hub. Ride the Metrocable for city views, explore the colorful street art of Comuna 13, and learn about the city’s history at Museo Casa de la Memoria.

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Day 6–7: Quito, Ecuador

Highlights: Historic Center, Middle of the World, Teleférico
Fly to Quito and adjust to the altitude. The UNESCO-listed historic center is filled with colonial architecture and bustling markets. Visit the Mitad del Mundo (Middle of the World) monument and ride the Teleférico up Pichincha Volcano for sweeping views of the Andes.

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Day 8–9: Cusco, Peru

Highlights: Plaza de Armas, San Pedro Market, Sacred Valley
Catch an early flight to Cusco, the gateway to the Sacred Valley and Machu Picchu. Spend time acclimating while exploring Inca ruins, traditional markets, and local Peruvian cuisine. Use this time to arrange your Machu Picchu ticket or tour if not booked in advance.

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Day 10: Machu Picchu, Peru

Highlights: Sunrise over the ruins, Huayna Picchu hike
Take the train to Aguas Calientes and visit the legendary Machu Picchu. Arrive early for the sunrise and hike up Huayna Picchu if you’ve secured a permit. Machu Picchu is a once-in-a-lifetime experience and the crown jewel of any South America trip.

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Day 11–12: La Paz, Bolivia

Highlights: Witches’ Market, Moon Valley, cable car rides
From Cusco, take a short flight or cross overland into Bolivia. La Paz is chaotic, colorful, and full of surprises. Ride the world’s highest urban cable car system, shop at the mysterious Witches’ Market, and explore the surreal Moon Valley just outside the city.

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Day 13–14: Salar de Uyuni, Bolivia

Highlights: Salt flats, cactus island, sunset reflections
Wrap up your trip with an unforgettable journey to the Salar de Uyuni. Book a 1- or 2-day tour to explore the world’s largest salt flat. You’ll witness otherworldly landscapes, colorful lagoons, and surreal reflection photos that seem to defy gravity.

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Travel Tips for Backpacking South America

• Pack light and smart: Choose quick-dry clothing, layers, and a secure daypack.
• Cash is king: While cards are accepted in cities, rural areas rely on cash.
• Learn basic Spanish: It goes a long way with locals and can help in tricky situations.
• Altitude awareness: Many stops are at high elevation—hydrate and acclimate slowly.
• Bus vs. flights: Overnight buses save on accommodation and are budget-friendly, but internal flights may save you days of transit.

Estimated Budget (Mid-range backpacker):

• Flights (regional & international): $700–$900
• Accommodation (hostels): $300–$400
• Food & drinks: $250–$350
• Local transport & entry fees: $250
• Machu Picchu + Uyuni tours: $300

Total: $1,800 – $2,200 USD

This 14-day backpacking itinerary through South America is intense but deeply rewarding. You’ll experience a wide variety of climates, landscapes, and cultures, making it one of the most dynamic and memorable trips you’ll ever take.